BUILDingHealth and Equity in East Portland was implemented in a historically under-served area with low levels of educational attainment and high rates of poverty. Population growth has outpaced the development of food access, and affordable housing, resulting in health inequities and social disparities. These barriers to health have resulted in high rates of chronic diseases, including diabetes, cardiovascular disease, asthma, and obesity. In East Portland, BUILD targeted the cycle of toxic stress, reduced chronic disease and its causes, promoted health equity, and reduced disparities. The partnership connected governmental, community, and business stakeholders to invest in the infrastructure of East Portland.